Comprehensive review highlighting the pregnancy microbiome as a key biomarker and intervention target to reduce preterm birth, including oral and gut microbiota.

Review summarizing oral bacteria detected in intrauterine cavity, their routes of dissemination, and consequences for pregnancy outcomes.

Cross-sectional study demonstrating that oral microbiota dysbiosis may contribute to pregnancy loss by disrupting immune function and metabolic processes.

Landmark study establishing the association between maternal periodontal disease and preterm birth/low birth weight.

Study investigating the relationship between oral microbiome and antenatal depression, highlighting microbiome measures as a promising biomarker.

Review summarizing how estrogen decline during perimenopause and menopause alters the oral microbiome, reduces salivary flow, and increases susceptibility to periodontal disease, xerostomia, and burning mouth symptoms.

Evidence linking declining estrogen to reduced collagen maintenance, accelerated alveolar bone loss, and a shift toward dysbiotic oral microbial communities in postmenopausal women.

High-confidence systematic reviews supporting the association between periodontal disease, tooth loss, and cardiovascular diseases.

Meta-analysis assessing non-surgical periodontal therapy impact on cardiovascular risk biomarkers including inflammatory markers and endothelial function.

Literature review covering studies from 2000-2024 examining the bidirectional relationship between oral health and cardiovascular disease.

Comprehensive review of molecular mechanisms linking periodontal disease and cardiovascular disease, including inflammatory pathways and bacterial translocation.

Direct detection of oral pathogens in coronary atherosclerotic tissue, supporting oral-systemic vascular pathways.

Investigation of associations between oral health issues (periodontitis and dental caries) and systemic health conditions including metabolic dysfunction.

Study demonstrating oral pathobiont induces systemic inflammation and metabolic changes associated with gut microbiota alteration.

Identification of P. gingivalis gingipains in Alzheimer's disease brains, with experimental evidence proposing a causal role in neurodegeneration.

Prospective study linking periodontal inflammation to accelerated cognitive decline in older adults with mild to moderate Alzheimer's disease.

Mechanistic review examining how oral bacteria and their inflammatory products cross the blood-brain barrier to contribute to neurodegeneration.

Evidence that periodontal disease contributes to systemic inflammatory burden via circulating inflammatory markers (CRP, IL-6).

Association between P. gingivalis antibody levels and rheumatoid arthritis severity and autoantibody production.

Evidence that oral bacteria can translocate to the gut and influence intestinal inflammation and colorectal cancer through metabolic pathways.

Review of complex connections between oral microbes and multiple human systemic diseases including cancer, cardiovascular, and autoimmune conditions.

Framework for understanding how imbalances in oral microbial communities lead to periodontal disease and systemic inflammation.

Study investigating how maternal health and oral microbiota during pregnancy affect the establishment of infant microbiome.

Comprehensive review highlighting the bidirectional relationship between oral health and systemic health with emerging mechanistic evidence.

Reference database cataloging over 700 prokaryotic species in the human oral cavity with phylogenetic and genomic information.